In today’s briefs on 3D printing, a standard proposed by ASTM International would define the properties of filaments. Mango 3D has announced a major update for its Lychee slicer. Finally, let’s move on to research, first focused on 3D printing technology that could advance biofilm science, and then on stem cell bioprinting for cardiovascular regeneration.
ASTM Development Standard for Properties of 3D Printing Filaments
A new standard is being developed by ASTM International that would be used to test the tensile properties of filaments. The proposed standard is being drafted by the organization’s F42 additive manufacturing technologies committee and will be used to determine baseline performance information and define properties for raw materials used in material extrusion 3D printers. the most common on the market.
Haibin Ning, member of ASTM International, is leading the development effort for this proposed standard and said it “can help users from laboratories to industries, especially aviation, aerospace, automotive and defense, to select the filament that meets their requirements. This can also facilitate quality control and optimization of filament production for manufacturers. These efforts are specifically linked to Sustainable Development Goals 9 and 12 on innovation and responsible consumption and production set by the United Nations.
Lychee Slicer launches new features and new user interface
Mango 3D offers a customizable operating system to manage 3D printing hardware and has announced that its 3D model preparation software, Lychee Slicer, has released an updated user interface for future projects, along with new features major and a more dynamic logo. The user interface has a cleaner look and is also more intuitive, to make print preparation quick and easy, and new features have been created to help reduce printing errors related to model size and facilitate the transition from virtual to real. Users can see the exact size of their future finished print using the new physical size mode, and another new feature is support painting, which speeds up the creation of manual supports.
“The confirmed success of Lychee Slicer with users, with more than 11 million slices generated, confirms our vision of 3D printing. This is a strong motivation for the development of our future projects,” said Thomas Roussel, CEO of Mango 3D. “We are aware of the limits and constraints of 3D printing, because we are passionate about 3D printing. We want to make this process accessible to as many people as possible. The democratization of 3D printers and the ever-growing communities are a great challenge in this path of simplification. However, we will do our best to answer them.
MSU researchers advance biofilm science with 3D printing
Biofilms – the slimy mats created when bacteria and various other microbes adhere to surfaces – form complex communities that are generally unaffected by normal disinfectants. But scientists at Montana State University’s Center for Biofilm Engineering are designing a 3D-printing system to replicate these communities so they can be studied and new treatments found. MSU doctoral students Isaak Thornton, mechanical engineering, and Kathryn Zimlich, microbiology, tested their system, which can lay out a precise grid of individual bacteria in a hydrogel and then solidify the material using laser light, creating this which is described as a “rudimentary” biofilm. The 3D printer will allow them to perform multiple passes with different strains and species of bacteria, which will then allow the creation of more complex layered biofilms. The fluorescent dye added to the bacteria allows researchers to easily see the microbes inside using special microscopes, so they can better study cellular interactions and develop treatments in a controlled setting.
Zimlich said: “One thing that is becoming clearer is that it is possible to treat these pathogenic bacteria by modifying the environment of the interactive biofilm instead of trying to use harsh chemicals.
“We believe it is possible to construct analogs of how these pathogenic biofilms form naturally.”
Thornton and Zimlich presented their work at the recent Montana Biofilm Meeting, which invites global researchers and industry partners to discuss biofilm science.
Bioprinting and tissue engineering for cardiovascular tissue regeneration
Finally, researchers from Stanford University, Graver Technologies in New Jersey, and the Center for Tissue Regeneration, Veterans Affairs Palo Alto Health Care System published a review article titled “Advances in three-dimensional bioprinted stem-based tissue engineering for cardiovascular regeneration”. 3D bioprinting produces tissues that mimic the function and structure of real tissues, such as cardiovascular tissues. Because bioprinted tissues can, as the team explained, “better recapitulate live physiology”, they can be used in many applications, such as disease modeling, drug testing and screening, in vitro cell studies, regenerative medicine and biocompatibility analysis. But, matrix molecules in bioprinted tissues cannot quite recreate the complexity of cellular morphologies and extracellular matrix; however, it is useful to include a vascular network, as well as patterned 3D bioprinted tissue. The researchers dig deeper into recent advances, applications, challenges and prospects of 3D bioprinting in their article.
“In this review, we summarize the next generation of 3D bioprinting techniques, the types of bioinks and printing materials used for 3D bioprinting, and the current state of the art of models modified cardiovascular tissues. We also highlight the translational applications of 3D bioprinting in the engineering of myocardial heart valves and vascular grafts. Finally, we discuss the current challenges and perspectives of designing effective 3D bioprinted constructs with native vasculature, architecture, and functionality for clinical translation and cardiovascular regeneration.
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